In drug discovery, the final sprint from lead optimization to candidate selection often depends on rapidly accessing metabolites, analogs, and late-stage functionalized derivatives. You often face the same, very familiar challenge. You have a highly optimized lead scaffold, but introducing a precise modification at the desired position can require lengthy synthetic routes, low-yielding chemistry, or extensive route redesign. At the same time, project timelines demand fast answers to critical questions around metabolism, structure-activity relationships, and candidate progression. While biocatalysis offers a powerful route to selective molecular editing, traditional enzyme discovery and optimization workflows are often incompatible with the speed required in modern medicinal chemistry programs.

Aminoverse delivers the tools matching your timelines: Introducing our tailored, ready-to-screen biocatalyst panels that are available off-the-shelf and shipped globally. The panels are designed for maximum easy-of-use requiring no prior experience in biocatalysis. If your inhouse capacities are spread thin, we can perform the panel screening on your compounds for you.

One example of how our off-the-shelf enzyme panels made metabolites readily accessible comes from a drug discovery partner who required the site-specific oxidation of a complex API intermediate:

• Aminoverse’s enzymes reacted on challenging regions of the compounds that were
inaccessible for traditional chemistry approaches
• Hydroxylation on 5/5 components detected
• Gram-scale metabolite delivery timeline shortened by 3 weeks