UPOs: Efficient oxygenation at scale
Unlock biocatalytic oxyfunctionalization with our 77 Unspecific Peroxygenase collection - ready-to-use, IP-free, and scalable from mg to kg.
Your Compounds
UPO Enzyme Panel
Unlock new biocatalysis with the largest collection of Unspecific Peroxygenases worldwide for the oxyfunctionalization of APIs, Key Intermediates, F&F compounds, novel materials, ingredients, agro- and speciality chemicals
- 77 UPOs – free of 3rd party IP
- Available from mg to kg scale
- CASE STUDIES
Proven Product Performance & Innovation
PROCESSING AID
How can you eliminate limiting impurities in DSP without compromising your API yield?
In API synthesis and pharmaceutical manufacturing, removing persistent, structurally related impurities remains a critical challenge. Traditional chemical purification steps occasionally lack the necessary selectivity, leading to significant product loss and high overhead in downstream processing (DSP)...
ALTERNATIVE SYNROUTES
Can biocatalysis enable an improved synthesis route?
For process chemists developing Active (Pharmaceutical) Ingredients, route scouting and optimization becomes challenging when synthesis pathways rely on costly starting materials and catalysts, multiple (de-)protection steps, low-yield transformations...
DRUG DISCOVERY
How can I get to my metabolite faster using enzymes?
In drug discovery, the final sprint from lead optimization to candidate selection often depends on rapidly accessing metabolites, analogs, and late-stage functionalized derivatives. You often face the same, very familiar challenge...
- WHY UPO ENZYMES
UPO enzyme advantages
Powerful, versatile, and scalable enzymes to unlock new chemistry, simplify synthesis routes, and accelerate your reactions.
Unlock New Chemistry
Convert challenging C-H bonds under mild, sustainable conditions with UPOs.
Made for Chemists
Ready-to-use lyophilized enzymes-no prior enzyme knowledge required.
Broad Substrate Scope
Efficiently oxidize diverse substrates with variable regio- and enantioselectivity.
Reactions That Scale
Biocatalytic reactions are scalable from mg to kg with simple hydrogen peroxide supplementation.
No IP Hassles
All UPOs are free of third-party IP-focus on your reaction, not licensing.
From Unspecific to Specific
Tailor UPOs for even higher yield and stability with over 10 years of enzyme engineering expertise.
Cheap Oxygen Supply
Hydrogen peroxide as only required co-factor. Say goodbye to NAD(P)H and molecular oxygen.
Unmatched Quality
Our UPOs are produced in Pichia pastoris - outcompeting E. coli-based preparations in yield and performance.
Robust and immobilizable
UPOs come with inherent stability to organic solvents, storage and perform well when immobilized.
- SCALE-UP READY
From mg screening to kg enzyme powder supply
Start with milligram-level enzyme tests, then move to kilogram powder quantities for pilot and production runs. Curated panels, reliable supply, and scale-ready delivery-all from one partner.
- NEXTGEN ENZYMES
P450 vs UPO
Cytochrome P450 Monooxygenases expanded the chemist’s toolkit and made their way into various biocatalytic applications. They do however come with plenty of drawbacks for cost efficient API production, especially at scale. UPOs represent the next generation of oxyfunctionalizing enzymes – with higher turnover, simpler handling and improved process robustness.
- our enzyme Products
Check out our other enzyme products
UPOs perform fascinating chemistry
I firmly believe UPOs can change the way we make chemistry and possibly these enzymes are the P450s we all were waiting for. If you are interested in screening our UPO Enzyme Panel, let's have a chat.
