We all have been there: Your synthetic route for a novel intermediate is established, but the efficiency has hit a ceiling and process economics are projected to break at scale.

The ever-recurring question: Is biocatalysis an alternative worth thinking about without major engineering efforts, especially for non-natural compounds?

Even when you can’t find any answer in literature, it does not mean the project is dead. At Aminoverse, we specialize in identifying enzymes with inherent catalytic promiscuity that allows them to accept complex, non-natural substrates. That is the easy part. The challenge is to find the ideal match between enzyme and compound to make sure you do not start at 1% conversion.

Our agentic EnzyNAV AI workflow ‘navigates’ the sequence space of enzymes and delivers those most suitable to your reaction and reaction conditions, be it a one-step or multi-step transformation.

Take the example of one of our CDMO partners, requiring a distinct modification on a complex, non- natural nucleotide derivate.

• Our EnzyNAV AI workflow identified 50 active phosphorylases (EC 2.4.) capable of handling
the non-natural substrate in a 2-step cascade
• The most promising candidates were produced in gram quantities to support immediate
industrial trials
• We delivered a full tech transfer package and a 2-step cascade reaching > 30 % yield in less
than 3 months – no enzyme engineering required