KGOs: Merging selective chemistry with scale
Curated ketoglutarate-dependent oxygenases for scalable, selective, and sustainable oxyfunctionalization chemistry
Your Compounds
KGO Enzyme Panels
A focused collection of alpha-ketoglutarate-dependent oxygenases covering a versatile group of enzymes critical to a wide range of chemical transformations.
- 100+ KGOs in 3 Panels: AminoAcid, BioCarbon, and XNA
- Available from mg to kg scale – free of 3rd party IP
- CASE STUDIES
Proven Product Performance & Innovation
ALTERNATIVE SYNROUTES
Can biocatalysis enable an improved synthesis route?
For process chemists developing Active (Pharmaceutical) Ingredients, route scouting and optimization becomes challenging when synthesis pathways rely on costly starting materials and catalysts, multiple (de-)protection steps, low-yield transformations...
NOVEL PATHWAYS
How to make my strain produce the product I need?
For strain engineers developing novel pathways, pathway feasibility starts long before host engineering. Enzyme discovery, substrate compatibility, cofactor requirements, and IP freedom-to- operate can determine whether a pathway is commercially viable or blocked by technical constraints. Still, enzyme evaluation is often overlooked during early strain design, resulting in costly redesign cycles later in development...
DRUG DISCOVERY
How can I get to my metabolite faster using enzymes?
In drug discovery, the final sprint from lead optimization to candidate selection often depends on rapidly accessing metabolites, analogs, and late-stage functionalized derivatives. You often face the same, very familiar challenge...
- Why KGO Enzymes?
Scalable & sustainable oxygenation chemistry
KGOs are stable, easy to produce, and capable of regio- and stereoselective transformations covering hydroxylation, epoxidation, halogenation, desaturation and ring formation under mild aqueous conditions. Like P450 Monooxygenases, just without the complecity and headaches.
- Why Curated Panels Matter?
Curated enzyme panels for faster discovery
Generic panels mean low coverage and wasted screening rounds. Our KGO panels are assembled using computational prediction and active-site profiling - focused on your substrate class from the start.
- SCALE-UP READY
From mg screening to kg enzyme powder supply
Start with milligram-level enzyme tests, then move to kilogram powder quantities for pilot and production runs. Curated panels, reliable supply, and scale-ready delivery - all from one partner.
- Our KGO Enzyme Panels
Three Panels. Three Discovery Pathways.
Each panel is optimized for a specific chemistry space
AminoAcid KGO Panel
Going beyond natural amino acids
40+ curated KGOs for targeted functionalization of canonical and non-canonical amino acids — purpose-built for peptide APIs, biomaterials, and advanced intermediates.
Example products:
trans-3-hydroxy-L-proline · 4-chloro-lysine · cis-3-hydroxy-L-pipecolic acid · 5-hydroxy-leucine
Best for: Pharma R&D, peptide chemistry, novel amino acid synthesis
BioCarbon KGO Panel
Precision biocatalysis for natural product modification
With 40+ curated KGOs, this panel enables selective oxyfunctionalization of alkaloids, fatty acids, steroids and terpenes. Designed for innovation in pharma, flavours & fragrances, agrochemicals, and bioactive compounds.
Example products:
gamma-dodecalactone, astaxanthin, cycloclavine, androstanone derivatives
Best for: Natural product chemistry, F&F, agro, bioactive discovery
XNA KGO Panel
Site-selective nucleic acid modification made accessible
This 25+ KGO enzyme panel unlocks precise modifications of nucleosides and nucleotides, enabling advanced tools for RNA therapeutics, synthetic biology, and molecular probes.
Example products:
5-formyluracil · 5-methyluridine · hydroxymethyluracil · modified nucleotides
Best for: RNA therapeutics, nucleic acid chemistry, biotech tools
- OUR ENZYME PRODUCTS
Check out our other enzyme products
KGOs perform fascinating chemistry for industrial applications.
Get in touch with Rainer if you are interested in screening our KGO Enzyme Panels.
What now?
Covering aspects like:
- We can supply up to kg scale of enzyme
- We can maximize yields by tuning the enzyme prodicess
- We can engineer the enzyme for superior performance
