BioCarbon KGO Enzyme Panel for hydroxylation of fatty acids, terpenes, alkaloids, and steroids
Introducing: The KGO Enzyme Panel “BioCarbon” – 28 curated biocatalysts for regio- and enantioselective hydroxylation of fatty acids, terpenes, alkaloids, and steroids.
Which biocatalysts?
KGO stands for Fe(II)-alpha-ketoglutarate-dependent Oxygenases, also abbreviated as 2OGs or αKGDs , are prone to react on non-activated C-H bonds and have a natural preference for metabolic compounds. The most frequent reaction is hydroxylation, but the enzymes are also capable of cyclopropanation and halogenation. KGOs react at ambient temperatures and pressure, utilizing alpha-ketoglutarate and O2 as cosubstrates for regio- and stereoselective modification.
Why curated?
Screening kits often yield limited or no hits. To overcome this, Aminoverse developed a curation pipeline that integrates bioinformatic mining, in silico biophysical simulations, and patent research. This approach evaluates enzyme candidates not only by homology or known function, but also with structural compatibility and predicted reactivity toward specific substrate classes. The resulting Biocarbon KGO panel with either experimentally validated or high-confidence predicted activity on fatty acids, terpenes, alkaloids, and steroids, increases your probability of a patentable success in a single screen.
Which biocatalysts?
KGO stands for Fe(II)-alpha-ketoglutarate-dependent Oxygenases, also abbreviated as 2OGs or αKGDs , are prone to react on non-activated C-H bonds and have a natural preference for metabolic compounds. The most frequent reaction is hydroxylation, but the enzymes are also capable of cyclopropanation and halogenation. KGOs react at ambient temperatures and pressure, utilizing alpha-ketoglutarate and O2 as cosubstrates for regio- and stereoselective modification.
Why curated?
Screening kits often yield limited or no hits. To overcome this, Aminoverse developed a curation pipeline that integrates bioinformatic mining, in silico biophysical simulations, and patent research. This approach evaluates enzyme candidates not only by homology or known function, but also with structural compatibility and predicted reactivity toward specific substrate classes. The resulting Biocarbon KGO panel with either experimentally validated or high-confidence predicted activity on fatty acids, terpenes, alkaloids, and steroids, increases your probability of a patentable success in a single screen.
What the curated KGOs can do for you:
– Creation of novel flavors and fragrances
– Development of bioactive agrochemicals
– Modification of hormones
– Synthesis of drug precursors
Advantages of the BioCarbon Kit:
– Enabling chemically challenging reactions
– Increased hit chances with a curated enzyme selection
– Speeds up R&D with a ready-to-screen format
Whether you are optimizing natural product scaffolds or developing new functionalities, the BioCarbon Kit is your shortcut to a high-probability discovery for biocatalytic oxyfunctionalization of fatty acids, terpenes, alkaloids, and steroids.
Intrigued to explore how the BioCarbon Kit can specifically advance your work and unlock novel compounds at scale?
Order here!
– Creation of novel flavors and fragrances
– Development of bioactive agrochemicals
– Modification of hormones
– Synthesis of drug precursors
Advantages of the BioCarbon Kit:
– Enabling chemically challenging reactions
– Increased hit chances with a curated enzyme selection
– Speeds up R&D with a ready-to-screen format
Whether you are optimizing natural product scaffolds or developing new functionalities, the BioCarbon Kit is your shortcut to a high-probability discovery for biocatalytic oxyfunctionalization of fatty acids, terpenes, alkaloids, and steroids.
Intrigued to explore how the BioCarbon Kit can specifically advance your work and unlock novel compounds at scale?