Enzyme Production
Custom enzyme production up to kg scale. 3 microbial hosts: E. coli, B. subtilis and P. pastoris
- Production workflow
Custom enzyme production & development
Aminoverse enables your enzyme projects with robust production platforms, vast genetic toolkits, and tailored solutions at every stage of your workflow.
Enzyme supply from µg to kg - in any format
We produce enzymes from microgram to kilogram scale with DSP tailored to your application - from crude whole cell to highly purified. Delivered with full QC in liquid, frozen, lyophilized or spray-dried powder form.
Three microbial hosts for optimized enzyme expression
Choosing the right host is key to every enzyme project. We offer tailored production in:
Escherichia coli (E. coli)
- Most commonly used prokaryotic platform, especially at early stages
- Fast growth and turnaround times with a large genetic toolkit
Bacillus subtilis (B. subtilis)
- Powerful enzyme secretion, especially for hydrolases or Bacillus-derived enzymes
- GRAS strain, no endotoxins, special non-sporulating strains
Pichia pastoris (P. pastoris)
- Eukaryotic GRAS host with natural post-translational modifications
- High secretory enzyme yields and efficient heme incorporation machinery
Streamlined production from start to finish
We design production protocols with precision:
- Upstream: Optimized strain, promoter, enhancers, signal peptide, codon usage, inducers, expression protocols and production vessels
- Downstream: Lysis, filtration, chromatography, centrifugation, dialysis, formulation, storage and quality control
Our in-house quality control ensures purity and enzyme activity before shipment.
- CASE STUDIES
Enzyme supply you can rely on
PROCESS CHEMISTRY
Scalable Biocatalysis: Producing non-natural compounds
We all have been there: Your synthetic route for a novel intermediate is established, but the efficiency has hit a ceiling and process economics are projected to break at scale. The ever-recurring question: Is biocatalysis an alternative worth thinking about without major engineering efforts, especially for non-natural compounds?
PROCESSING AID
How can you eliminate limiting impurities in DSP without compromising your API yield?
In API synthesis and pharmaceutical manufacturing, removing persistent, structurally related impurities remains a critical challenge. Traditional chemical purification steps occasionally lack the necessary selectivity, leading to significant product loss and high overhead in downstream processing (DSP)...
SUPERIOR PERFORMANCE
My enzyme needs higher thermostability to beat all competitors’ products in the market
You are almost there: your candidate enzyme is highly active and performs well in development, but its thermostability still falls short of market requirements. In feed applications, insufficient thermal tolerance during processing can directly impact product performance, process robustness...
- OUR PRODUCTS
Enzyme research products
Create new chemistry with our unique collection Off-the-shelf biocatalysts
UPO Enzyme Panel
- 77 Unspecific Peroxygenases
- from mg to kg scale - free of 3rd party IP
KGO Enzyme Panels
- 133 ketoglutarate dep. oxygenases
- from mg to kg scale - free of 3rd party IP
Lipase Enzyme Panels
- 9 Lipases - free and immobilized
- from mg to kg scale - free of 3rd party IP
Human CYP Enzyme Panel
- 8 human CYPs/P450s for Discovery and LSF
- from mg to kg scale
Other Panels
- KREDs, TAs, IREDs, ADHs and more. We can buy and screen any enzyme panel currently available on the market through our collaboration with Prozomix, one of the top suppliers for enzyme panels.
Custom Enzyme Panels
- You could not find a commercial source of your desired enzymes? We gladly provide you with a customized enzyme panel of your choice.
- Receive a collection of 5–50 enzymes curated for your target reaction and process conditions. The enzymes are either selected by our customers directly, e.g., from scientific literature, or we perform an enzyme discovery study to find the most promising enzymes in nature.
- our services
The one-stop shop to deliver all your enzyme needs
Start with the end in mind
The future production of your enzyme will make or break your business case. Choosing the right strategy and host from the start ensures a smooth transition from lab to scale.
Wondering how to approach the production of your enzyme?