UPO ENZYME PANEL

Biocatalysis – power on!

    Revolutionize your API syn route by using biocatalysis for the oxyfunctionalization and dealkylation of your compound in hours. We offer the world’s largest collection of unspecific peroxygenase enzymes (UPOs) in a ready-to-use enzyme panel for rapid testing.

    Download the UPO Enzyme Panel brochure for more detailed information.

    PDF (283 KB)

    NO MORE IRIDIUM

    Unlock new chemistry

    The oxyfunctionalization of non-activated C-H bonds is a chemically challenging process, typically requiring exotic materials and Iridium catalysts. Nature offers a powerful alternative: Unspecifc peroxygenases are enzymes capable of introducing oxygen virtually anywhere and open up new syn route options – under sustainable, physiological conditions.

    ADD – MIX – ANALYZE

    Made for chemists

    The UPO Enzyme Panel is made for chemists to quickly test the biocatalytic conversion of the desired substrate and detect the target compound. No prior knowledge about enzymes required – simply use them as any other catalyst.

    UNSPECIFIC – LITERALLY

    Broad substrate scope

    Thanks to their unspecific nature, UPOs are able to convert a broad range of substrates with varying regio- and enantioselectivity. This renders them ideal biocatalyst for oxidative reactions that are chemically very challenging.

      LAB IS NOT THE LIMIT

      Reactions that scale

      Biocatalytic reactions involving unspecific peroxygenases are scalable! The enzymes only require hydrogen peroxide as oxygen donor which can be continously supplemented or regenerated during the reaction via an enzymatic side reaction.

      And we scale with you: We can supply our UPOs up to kg scale.

       

      Feature
      P450
      UPO
      Size > 100 kDa < 50 kDa
      Subunits Yes, 1-3 No
      Co-Factor NAD(P)H, O2 H2O2
      Reaction Stability ++
      Producibility ++
      Handling ++
      Oxygen Dilemma Yes, up to 90% product loss No
      Reaction Cost $$$ $

       

       

      NEXTGEN ENZYMES

      P450 vs UPO

      Cytochrome P450 Monooxygenases expanded the chemist’s toolkit and made their way into various biocatalytic applications. They do however come with plenty of drawbacks for cost efficient API production, especially at scale. UPOs represent the next generation of oxyfunctionalizing enzymes – at scale.

      UNHINDERED SCIENCE

      No IP hassles

      There can be many obstacles on the way towards an innovative API production process. We believe, enzyme IP should not be one of them.

      All enzymes contained in the UPO Enzyme Panel are free of third-party IP so that you may focus on finding the UPO that suits your reaction – and scale it.

      REACTION OPTIMIZATION

      From unspecific to specific

      Having found a UPO catalyzing your reaction, there is often room to further boost product yield and reaction stability, e.g. by engineering the unspecific peroxygenase to a specific one. As it happens, we engineer enzymes for more than 10 years and we gladly provide you with an engineered UPO tailored to your needs.

      Check out our Enzyme Services for more information.

      OUR PARTNER

      Together makes better science

      The UPO Enzyme Panel is a joint development of Aminoverse and BISY to ensure cutting edge enzyme science and supply.

        Bisy GmbH

        Wuenschendorf 292
        8200 Hofstaetten a. d. Raab
        AUSTRIA

        www.bisy.at

        You can directly order the UPO Enzyme Panel here

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