UPO ENZYME PANEL
Biocatalysis – power on!
Revolutionize your API syn route by using biocatalysis for the oxyfunctionalization and dealkylation of your compound in hours. We offer the world’s largest collection of unspecific peroxygenase enzymes (UPOs) in a ready-to-use enzyme panel for rapid testing.
Download the UPO Enzyme Panel brochure for more detailed information.
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NO MORE IRIDIUM
Unlock new chemistry
The oxyfunctionalization of non-activated C-H bonds is a chemically challenging process, typically requiring exotic materials and Iridium catalysts. Nature offers a powerful alternative: Unspecifc peroxygenases are enzymes capable of introducing oxygen virtually anywhere and open up new syn route options – under sustainable, physiological conditions.
ADD – MIX – ANALYZE
Made for chemists
The UPO Enzyme Panel is made for chemists to quickly test the biocatalytic conversion of the desired substrate and detect the target compound. No prior knowledge about enzymes required – simply use them as any other catalyst.
UNSPECIFIC – LITERALLY
Broad substrate scope
Thanks to their unspecific nature, UPOs are able to convert a broad range of substrates with varying regio- and enantioselectivity. This renders them ideal biocatalyst for oxidative reactions that are chemically very challenging.
LAB IS NOT THE LIMIT
Reactions that scale
Biocatalytic reactions involving unspecific peroxygenases are scalable! The enzymes only require hydrogen peroxide as oxygen donor which can be continously supplemented or regenerated during the reaction via an enzymatic side reaction.
And we scale with you: We can supply our UPOs up to kg scale.
Feature |
P450 |
UPO |
| Size | > 100 kDa | < 50 kDa |
| Subunits | Yes, 1-3 | No |
| Co-Factor | NAD(P)H, O2 | H2O2 |
| Reaction Stability | – | ++ |
| Producibility | – | ++ |
| Handling | – | ++ |
| Oxygen Dilemma | Yes, up to 90% product loss | No |
| Reaction Cost | $$$ | $ |
NEXTGEN ENZYMES
P450 vs UPO
Cytochrome P450 Monooxygenases expanded the chemist’s toolkit and made their way into various biocatalytic applications. They do however come with plenty of drawbacks for cost efficient API production, especially at scale. UPOs represent the next generation of oxyfunctionalizing enzymes – at scale.
UNHINDERED SCIENCE
No IP hassles
There can be many obstacles on the way towards an innovative API production process. We believe, enzyme IP should not be one of them.
All enzymes contained in the UPO Enzyme Panel are free of third-party IP so that you may focus on finding the UPO that suits your reaction – and scale it.
REACTION OPTIMIZATION
From unspecific to specific
Having found a UPO catalyzing your reaction, there is often room to further boost product yield and reaction stability, e.g. by engineering the unspecific peroxygenase to a specific one. As it happens, we engineer enzymes for more than 10 years and we gladly provide you with an engineered UPO tailored to your needs.
Check out our Enzyme Services for more information.
OUR PARTNER
Together makes better science
The UPO Enzyme Panel is a joint development of Aminoverse and BISY to ensure cutting edge enzyme science and supply.
