XNA KGO Enzyme Panel for functionalization of DNA, RNA, and their derivatives

Working on selective functionalization of nucleoside structures, but struggling with enzyme screens for RNA, DNA, or their derivatives, often ending up with few or no hits?

Aminoverse introduces the KGO Enzyme Panel “XNA” — 22 curated Fe(II)-α-ketoglutarate-dependent oxygenases for regio- and stereoselective modification of nucleosides, nucleotides and similar substrates.

Which biocatalysts?
KGOs (Fe(II)-α-ketoglutarate-dependent oxygenases, also known as 2-oxoglutarate-dependent oxygenase or α-ketoglutarate-dependent dioxygenase are nature’s versatile catalysts for non-activated C–H bonds. They have a natural preference for metabolic and nucleic acid-related compounds. While hydroxylation is their dominant activity, KGOs are also capable of halogenation and cyclopropanation. Operating under mild, aqueous conditions with α-ketoglutarate and O₂ as co-substrates, they bring regio- and stereoselective power to RNA and DNA transformations.

Why curated?
Generic enzyme panels often deliver low hit rates. At Aminoverse, we built a curation pipeline that combines bioinformatic mining, in silico biophysical simulations, and patent landscaping. Instead of relying only on homology, we prioritize enzymes with predicted structural compatibility and reactivity toward nucleic acid scaffolds. The result is our XNA KGO Panel: biocatalysts with either validated or high-confidence predicted activity on RNA, DNA, and derivatives. This targeted selection dramatically increases your chances of identifying a patentable hit in a single screen.

What curated KGOs can do for you
–      Site-selective modification of nucleosides and nucleotides
–      Access to novel nucleic acid derivatives for pharma and biotech
–      Functionalization of oligonucleotides for therapeutic applications
–      Creation of tools for synthetic biology and molecular probes

Advantages of the XNA Kit
–      Ready-to-screen format accelerates R&D
–      Unlocks transformations that are chemically challenging or inaccessible
–      Higher hit rates thanks to targeted curation

Whether you are advancing RNA therapeutics, exploring DNA modification tools, or engineering nucleic acid derivatives, the XNA Kit is your shortcut to high-probability discovery.

Interested in pushing the boundaries of nucleic acid chemistry? Connect with us to order your Aminoverse XNA KGO Kit today.